Effects of Homogentisic Acid and Natural Products Derived from Pinellia ternata on Secretion, Production and Gene Expression of MUC5AC Mucin from Cultured Airway Epithelial Cells
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Effect of Chrysin on Gene Expression and Production of MUC5AC Mucin from Cultured Airway Epithelial Cells
BACKGROUND We investigated whether chrysin affected MUC5AC mucin production and gene expression induced by phorbol ester (phorbol 12-myristate 13-acetate, PMA) or epidermal growth factor (EGF) from human airway epithelial cells. METHODS Confluent NCI-H292 cells were pretreated with varying concentrations of chrysin for 30 minutes, and were then stimulated with PMA and EGF for 24 hours, respec...
متن کاملEffects of Lobetyolin, Lobetyol and Methyl linoleate on Secretion, Production and Gene Expression of MUC5AC Mucin from Airway Epithelial Cells
BACKGROUND In this study, we investigated whether lobetyolin, lobetyol, and methyl linoleate derived from Codonopsis pilosula affect MUC5AC mucin secretion, production, and gene expression from airway epithelial cells. METHODS Confluent NCI-H292 cells were pretreated with lobetyolin, lobetyol, or methyl linoleate for 30 minutes and then stimulated with phorbol 12-myristate 13-acetate (PMA) fo...
متن کاملEffects of Lupenone, Lupeol, and Taraxerol Derived from Adenophora triphylla on the Gene Expression and Production of Airway MUC5AC Mucin
BACKGROUND Adenophora triphylla var. japonica is empirically used for controlling airway inflammatory diseases in folk medicine. We evaluated the gene expression and production of mucin from airway epithelial cells in response to lupenone, lupeol and taraxerol derived from Adenophora triphylla var. japonica. METHODS Confluent NCI-H292 cells were pretreated with lupenone, lupeol or taraxerol f...
متن کاملEffect of Ambroxol on Secretion, Production and Gene Expres- sion of Mucin from Cultured Airway Epithelial Cells
pharmacological means to inhibit mucin secretion and/or production has become an important approach to regulate the hypersecretion of airway mucus (Mutschler and Derendorf, 1995). Secretion of airway mucin is generally stimulated by various agents. Whereas glucocorticoids inhibit the hypersecretion of airway mucins (Mutschler and Derendorf, 1995; Lee et al., 2002), they have various limitations...
متن کاملRegulated Mucin Secretion from Airway Epithelial Cells
Secretory epithelial cells of the proximal airways synthesize and secrete gel-forming polymeric mucins. The secreted mucins adsorb water to form mucus that is propelled by neighboring ciliated cells, providing a mobile barrier which removes inhaled particles and pathogens from the lungs. Several features of the intracellular trafficking of mucins make the airway secretory cell an interesting co...
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ژورنال
عنوان ژورنال: Natural Product Sciences
سال: 2017
ISSN: 1226-3907,2288-9027
DOI: 10.20307/nps.2017.23.1.29